department of pharmacology

Yoshikazu Imanishi, Ph.D.

Yoshikazu Imanishi, Ph.D.

Associate Professor
Director of Light Microscopy Imaging Core

Phone: (216) 368-5226
Fax: (216) 368-1300
W515 Wood Building



Localization of proteins and chemical intermediates invloved in phototransduction and the visual cycle using modern imaging technique

Field of study:
Cell Biology of Photoreceptor Morphogenesis.

Selected References:
  • Imanishi Y, Gerke V, Palczewski K. Retinosomes: new insights into intracellular managing of hydrophobic substances in lipid bodies. J Cell Biol 2004;166:447-453.
  • Imanishi Y, Batten ML, Piston DW, Baehr W, Palczewski K. Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye. J. Cell Biol. Feb 2004;164: 373-383.
  • Imanishi Y, Yang L, Sokal I, Filipek S, Palczewski K, Baehr W. Diversity of Guanylate Cyclase-Activating Proteins (GCAPs) in Teleost Fish: Characterization of Three Novel GCAPs (GCAP4, GCAP5, GCAP7) from Zebrafish (Danio rerio) and Prediction of Eight GCAPs (GCAP1-8) in Pufferfish (Fugu rubripes). J Mol Evol 2004; 59:204–217
  • Haeseleer F, Imanishi Y, Maeda T, Possin DE, Maeda A, Lee A, Rieke F, Palczewski K. Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. Nature Neuroscience 2004;7: 1079-1087
  • Batten ML, Imanishi Y, Maeda T, Tu D, Moise AR, Bronson D, Possin D, Van Gelder RN, Baehr W, Palczewski K. Lecithin:retinol acyltransferase (LRAT) is essential for retention of retinyl esters in the eye and in the liver. J Biol Chem. 2004 Mar; 279(11):10422-32


Leica TCS SP2 multiphoton Microscope