CENTER FOR MEMBRANE BIOLOGY
Members
Focco van
den Akker, Ph.D.
Assistant Professor,
Department of Biochemsitry
Phone: (216) 368-8511; Fax: (216) 368-3419
E-mail: fxv5@case.edu
Multi-facetted structural approach to understanding the molecular signal
transduction events of membrane receptors important for blood pressure
regulation and bone growth, and other enzymes
Cathleen Carlin, Ph.D.
Professor and Interim Chair,
Department of Physiology & Biophysics
Phone: (216) 368-8939; Fax: (216) 368-3952
E-mail: cxc39@case.edu
Role of membrane receptor ErbB trafficking in normal cell physiology and in human
pathological states. The cellular mechanisms involved in development and
maintenance of epithelial cell polarity.
Chris Dealwis, Ph.D.
Associate Professor
Phone: (216) 368-1652, 368-3337; Fax: (216) 368-1300
E-mail: chris.dealwis@case.edu
SOM W303A
Research: To study the structure-function relationship of macromolecules using
structural biology and biochemical tools.
George R. Dubyak, Ph.D.
Professor,
Department of Physiology & Biophysics
Phone: (216) 368-5523; Fax: (216) 368-3952)
E-mail: gxd3@case.edu
Nucleotide-based signal transduction in the physiological role of extracellular
nucleotides and P2 nucleotide receptors as regulators of inflammation, innate
immunity, and cardiovascular function.
Ulrich Hopfer, Ph.D.
Professor,
Department of Physiology & Biophysics
Phone: (216) 368-2878; Fax: (216) 368-3952
E-mail: uxh@case.edu
Molecular and morphological basis of active trans-epithelial transport including
studies that encompass molecular mechanisms of membrane transport, energization
of transport, and cellular regulation and integration of different signaling
pathways and transporters to achieve trans-epithelial transport.
Charles L. Hoppel, MD
Professor of Medicine,
Division of Clinical Phamacology,
Phone: 216-844-5359; Fax (216) 368-3395
E-mail: clh5@case.edu
Study of the mitochondrial contact sites that contain the protein translocases
for protein translocation into the mitochondria and the peripheral
benzodiazepine receptor.
Yoshikazu Imanishi, Ph.D.
Acting Director, Center for Membrane Biology
Assistant Professor,
Department of Pharmacology
Phone: (216) 368-; Fax: (216) 368-
E-mail: yxi19@case.edu
Cell biology of RPE-photoreceptor cell interactions.
Stephen Jones, Ph.D.
Professor,
Department of Physiology & Biophysics
Phone: (216) 368-5527; Fax: (216) 368-3952
E-mail: swj@case.edu
Studies on voltage-dependent channels, the basis of electrical activity and
signaling in the membranes of neurons and other "excitable" cells.
Michael E. Maguire, Ph.D.
Professor,
Department of Pharmacology
Phone: (216) 368-6187; Fax: (216) 368-3395
E-mail: mem6@case.edu
Multiple roles of Mg2+ and Mn2+ in
bacterial metabolism and pathogenesis using primarily Salmonella enterica
serovar Typhimurium (S. Typhimurium) as a model system.
John J. Mieyal, Ph.D.
Professor, Department Vice Chair
Department of Pharmacology
Phone: (216) 368-3384; Fax: (216) 368-3395
E-mail: jjm5@case.edu
Modulation of the thiol-disulfide status of critical cysteine residues on
proteins - an important mechanism of oxidative signal transduction as well as an
important consequence of oxidative stress associated with aging and various
disease states.
Krzysztof Palczewski, Ph.D.
Professor, Chair
Department of Pharmacology
Phone: (216) 368-4631; Fax: (216) 368-1300
E-mail: kxp65@case.edu
G-protein-coupled receptor mediated signal transduction and retinoids in vision.
Virgil Muresan, Ph.D.
Assistant Professor,
Department of Physiology & Biophysics
Phone: (216) 368-4766; Fax: (216) 368-3952
E-mail: vxm28@case.edu
Transmission of signals from one part of the cell to the other, relying on the
transport of organelles and protein complexes to specific intracellular
destinations.
Frank Sönnichsen, Ph.D.
Associate Professor,
Department of Physiology & Biophysics
Phone: (216) 368-5405; Fax: (216) 368-1693
E-mail: fds@case.edu
Investigation of the structure-function relationships of membrane proteins from
mycobacterium tuberculosis using solution NMR spectroscopy. Sorting and
trafficking of the epidermal growth factor receptor.
Vivien Yee, Ph.D.
Professor,
Department of Biochemistry
Phone: (216) 368-1184; Fax (216) 368-3419
E-mail: vcy2@case.edu
Structural studies of biomedically important proteins in the cell membrane
including proteins involved in blood clotting, neurodegenerative disorders and
antiviral defense, and model systems for metabolic enzymes.